The missing link: TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry

The missing link: TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry

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Most cell entry by FLORA DA RESERVA DUCKE, AMAZONAS, BRASIL invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol.This process frequently inflicts membrane damage and provokes a cellular response.This Autophagic Punctum summarizes our recent study investigating how adenovirus endosome penetration is recognized and activates macroautophagy/autophagy.Our key finding is that TBK1 (TANK binding kinase 1) has a dual role in the cell response to membrane damage; it is part of an immediate-acting membrane-damage-sensing complex and is a Generating User Privacy-Controllable Synthetic Data for Recommendation Systems crucial driver of the resulting autophagic response.

Thus, TBK1 is a central factor linking sensors and effectors during the cell response to membrane damage.